CORDIS Project
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This project investigates the role of microglial cells in amyotrophic lateral sclerosis (ALS), focusing on their interaction with motor neurons. It aims to uncover mechanisms of neurotoxicity and potential therapeutic targets for ALS.
Amyotrophic Lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting motor neurons and leading to paralysis and death of the patients.
Missense mutations in the gene for the ubiquitously expressed Cu/Zn superoxide dismutase (SOD1) are the best known cause for familial ALS leading to motor neuron death through an acquired toxic function still unidentified.
Mice expressing ubiquitously mutant SOD1 develop ALS and although paralysis arises from death of motor neurons it is now…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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