CORDIS Project
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This project explores the biology of glioblastoma stem cells and their response to Notch pathway inhibitors. By isolating these cells from patients and analyzing their genetic responses, the research aims to identify potential therapeutic targets for treating glioblastoma, a highly aggressive brain tumor.
Glioblastoma multiforme (GBM) is the most common malignant intracranial tumor in adults.
Despite the knowledge of the genetic alterations associated to GBM and the improvement in neurosurgery and chemo- and radiotherapy, little improvement has been achieved in the median survival.
Recently, glioma stem cells (GSCs) have been identified to be responsible of the origin, recurrence and drug resistance in GBM, constituing so an attractive therapeutic target in the fight against gliomas.
The present…
FUNDACION PRIVADA INSTITUTO DEINVESTIGACION ONCOLOGICA DE VALL-HE
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
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