CORDIS Project
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This research investigates the role of type III Neuregulin1 in the development of myelinating glial cells, crucial for neuronal health. By studying the mechanisms of myelination and the effects of specific protein cleavage, the project aims to uncover therapeutic strategies for promoting nerve regeneration.
The development of glial cells, oligodendrocytes (OL) in CNS and Schwann cells (SC) in PNS, critically depends on axonal contact.
Gliogenesis and the phenotype of myelinating glia are regulated by axons.
Glial cells promote neuronal survival, regulate the organization of myelinated axons and promote axonal differentiation and myelin sheath production.We recently showed that type III NRG1, a member of the Neuregulin1 (NRG1) family of proteins, is an essential instructive signal for myelination in…
OSPEDALE SAN RAFFAELE SRL
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