CORDIS Project
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This project explores the role of the Cullin7 E3 ubiquitin ligase in insulin signaling and its implications for diabetes. It aims to clarify how this regulator affects insulin response and contributes to insulin resistance.
This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes.
My previous work led to the identification of insulin receptor substrate 1 (IRS-1) as the proteolytic target of the CUL7 E3 ligase and uncovered CUL7 as a novel regulator of insulin signaling.
Based on these observations, I will employ experimental strategies as outlined in this proposal to delineate CUL7`s role for the cellular insu…
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