CORDIS Project
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This project investigates the role of the Grhl1 gene in skin cancer, focusing on its potential function as a tumor suppressor. By studying Grhl1-deficient mice, the research aims to understand tumor development in response to chemical carcinogens and UV radiation, analyzing gene expression and cellular processes involv…
Many functions of the Grainyhead-like (Grhl) transcription factors have already been studied in various animal models.
So far these studies have been primarily concerned with the roles of such factors in development and wound healing.
Now we have new preliminary data indicating that the Grhl factors are potential novel tumor suppressors.
We have already established that the Grhl1-deficient mice have increased susceptibility to chemically induced cutaneous tumor development.
We have also generate…
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
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