CORDIS Project
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This project explores the mechanisms behind the vulnerability of specific neurons in the brain related to Parkinson's disease. It focuses on how the loss of dopamine-producing neurons affects motor functions and habit formation, aiming to clarify the relationship between brain structure and disease progression.
Parkinson’s disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc).Understanding the mechanisms underlying the onset and progression of SNpc damage
is a primary unmet goal in PD research.Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc.Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc:their large axonal
arborisations,bursting a…
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