CORDIS Project
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This project focuses on retinitis pigmentosa, a hereditary retinal disorder leading to blindness. It aims to create an animal model to study the effects of increasing the expression of the PRPF31 gene, which is linked to a common form of the disease, using RNA interference and gene delivery techniques.
With a prevalence of 1 in 3500 retinitis pigmentosa (RP) is a significant cause of blindness in the Western world. RP is a group of hereditary retinal disorders, for which there is no effective treatment.
It is mostly caused by mutations in genes related to the biochemistry of photoreceptors. PRPF31, however was the first ubiquitously expressed gene implicated in this disorder.
Mutations in this gene are responsible for one of the commoner forms of autosomal dominant RP (RP11) with implications…
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
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