CORDIS Project
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This project focuses on understanding the regulation of protein degradation systems, specifically autophagy and the ubiquitin-proteasome system. It aims to uncover the molecular mechanisms that ensure substrate specificity, which is crucial for maintaining cellular health and preventing diseases.
Cell growth and division are tightly regulated by phosphorylation and selective degradation of cellular components.
Whereas autophagy is mainly responsible to eliminate long-lived proteins and organelles, the ubiquitin-proteasome system (UPS) rapidly degrades proteins when fast adaptation is needed.
Defects in these degradation systems accounts for numerous human diseases, including cancer, muscle dystrophies, viral and bacterial infections and neurodegeneration.
While rapid progress has been ma…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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