CORDIS Project
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This project develops new ruthenium catalysts for late-stage functionalization of complex bioactive molecules. By enabling the modification of C-H bonds under mild conditions, it aims to accelerate drug discovery and improve the synthesis of agrochemicals and organic materials.
A 2018 joint report from pharma identified organic synthesis as one of the major bottlenecks in drug discovery today.
In the highly competitive discovery environments, only fast-to-synthesise molecules are targeted, based mostly on five well-tested and proven synthetic methods.
This approach has led to only a small portion of the chemical shape space being explored over the last decades and has been partly blamed for the recent low success rates in new drug development.
The report emphasises the…
THE UNIVERSITY OF MANCHESTER
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