CORDIS Project
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This project investigates the mechanisms of chromosome segregation during the early divisions of mammalian embryos. By utilizing advanced microscopy and genetically modified mice, the research aims to enhance understanding of chromosomal abnormalities that can lead to infertility.
Meiotic divisions in the oocyte have been shown to be surprisingly error-prone compared to the reliable chromosome segregation that takes place in dividing somatic cells.
The high frequency of chromosomal abnormalities found in pre-implantation embryos in mammals coupled with the fact that the first divisions of the embryo resembles meiosis in several aspects suggests that the mechanisms controlling chromosome segregation, most importantly the spindle assembly checkpoint (SAC), only become fully…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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