CORDIS Project
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This project focuses on understanding how protein complexes adapt their structure in response to local changes, using advanced mass spectrometry techniques. It aims to study viral protein complexes, particularly those associated with coronaviruses, to gain insights into their flexible nature.
The main question to be addressed by SPOCk’S MS is how protein complex conformation adapts to local changes, such as processing of polyproteins, protein phosphorylation or conversion of substrates.
While labelling strategies combined with mass spectrometry (MS), such as hydrogen deuterium exchange and hydroxyl footprinting, are very versatile in studying protein structure, these techniques are employed on bulk samples averaging over all species present. SPOCk’S MS will remedy these by studying t…
LEIBNIZ-INSTITUT FUR VIROLOGIE
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