CORDIS Project
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This project is developing innovative nanoscale systems to effectively bind heparin, an anticoagulant used in surgeries. The goal is to create synthetic alternatives to protamine that minimize allergic reactions while ensuring efficient heparin removal.
This proposal targets the development of self-assembling nanoscale systems to bind heparin.
Heparin is widely used as an anti-coagulant during major surgery, but once surgery is complete, it is necessary to remove the heparin and allow clotting to begin.
The current therapy is protamine, a protein extracted from shellfish which acts as a powerful heparin binder, but unfortunately, causes allergic response and other problems in significant numbers of patients (ca. 10%).
We are therefore target…
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