CORDIS Project
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The project investigates the structural and signaling roles of titin and nebulin in muscle contraction and remodeling. By collaborating internationally, researchers aim to enhance understanding of muscle biology and develop resources for studying muscle-related diseases.
The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction.
Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions:
Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded into the sarcomere.
Thereby, titin and nebuliun with dual structural scaffold and biosensing functions…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Lithuania, Vilnius
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
France, Illkirch Graffenstaden
Type: Research institute
Activity type: Research Organisations
SME: No
United Kingdom, Liverpool
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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