CORDIS Project
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This project investigates how Rad51 paralogs enhance the function of Rad51 in repairing DNA double-strand breaks. By employing advanced techniques in structural biology and biophysics, the research aims to clarify the molecular mechanisms of homologous recombination, which is crucial for maintaining genome stability an…
Homologous recombination (HR) is a major mechanism for repairing DNA double-strand breaks (DSBs). A DSB converts one normal chromosome into two pathological chromosomes, making it the severest form of DNA damage.
Accordingly, defects in HR lead to genome instability, a potent driver of tumorigenesis.
Although Rad51 is the central enzyme involved in HR, several auxiliary factors promote HR by stimulating Rad51.
Rad51 paralogs comprise one family of evolutionarily conserved auxiliary factor.
Unlik…
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