CORDIS Project
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This project explores the role of satellite cells in muscle regeneration, focusing on the molecular mechanisms that influence their activation and differentiation. It utilizes advanced technologies to analyze the interactions within the satellite cell niche and their impact on muscle repair.
Skeletal muscle stem cells (satellite cells - SCs), are undifferentiated progenitors that reside mitotically quiescent in a specialized anatomical niche between the plasma membrane of muscle fibres and the basal lamina: the SC niche. SCs can remain quiescent for long periods of time, but in response to injury become rapidly activated, proliferate and then undergo terminal differentiation.
The molecular mechanisms that coordinate the multiple signals involved in regulation of SC fate decisions ar…
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