CORDIS Project
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This project investigates the role of the Piezo1 calcium channel in the development of arteriovenous malformations (AVMs) by examining how shear stress influences vascular remodelling and Notch signalling. The research aims to identify new targets for diagnosing and treating both hereditary and idiopathic AVMs.
Arteriovenous malformations (AVMs) are characterised by abnormal connections between arteries and veins due to defects during vascular remodelling.
Although often asymptomatic, AVMs can cause intense pain and patients affected present higher risk for strokes and aneurysms.
Hereditary AVMs have a prevalence of 18 in 100000 people causing a two-fold increase in mortality in patients younger than 60 years of age.
Hereditary AVMs are linked to defective Notch/BMP signalling, however they represent…
UNIVERSITY OF LEEDS
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