CORDIS Project
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This project investigates the mechanisms behind neurodegenerative diseases using a model derived from patients with spinal and bulbar muscular atrophy. It aims to understand the molecular processes involved and identify potential therapeutic drugs to treat these conditions.
Accumulation of toxic aggregation-prone protein into inclusions and aggregates is the hallmark of most neurodegenerative diseases, a broad class of disorders including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and polyglutamine diseases.
In this proposal, using SBMA as a model of neurodegenerative polyglutamine-related disorder, we intend to move a step forward expanding knowledge of the neurodegeneration.
In particular, we will provide a suitable model system such…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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