CORDIS Project
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This project aims to understand the relationship between epigenetic changes and gene expression during cell differentiation. By developing a novel method to analyze histone modifications at the single-cell level, the research seeks to map the order of these changes as cells transition between differentiation stages.
Past research has identified epigenetic mechanisms including histone modifications as key regulators of transcription and implicated them in cellular differentiation.
But while our knowledge about their cell type specific distribution and its influence on transcription has constantly increased, we still know very little about the orchestration of epigenetic and transcriptional changes as they occur during differentiation.
To gain a global understanding of the order of events, we aim to identifyi…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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