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The sc-LAB2FATE project aims to explore how single cells in zebrafish embryos differentiate over time. By utilizing a novel RNA labeling technique, it seeks to uncover the dynamics of cell fate changes during development, providing insights into both programmed and self-organized processes in embryogenesis.
Every time an egg is fertilised, the cellular diversity of an animal must be rebuilt from scratch.
Therefore, a central question in developmental biology is how cells differentiate to acquire distinct fates. A combination of genetics, molecular biology, and microscopy approaches has led to fundamental discoveries.
Recently, single-cell genomics has enabled the analysis of transcriptional differentiation trajectories at unprecedented scale and resolution.
However, ordering single cells by transcr…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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