CORDIS Project
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This project aims to enhance our understanding of early mammalian development by integrating spatial transcriptomics and in toto imaging techniques. By linking cellular dynamics with gene expression profiles, it seeks to reveal how cells behave and differentiate during critical developmental stages.
Mammalian early embryonic development requires exquisite spatiotemporal gene regulation at the level of individual cells.
However, it is still unclear and remains a fundamental challenge how cell behaviours govern gastrulation and organogenesis in early embryos.
Two techniques have recently been developed to investigate cell fate decisions in early mammalian development (spatial transcriptomics at single-cell level) or to study the dynamic transition from single cells to fully formed organisms (…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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