CORDIS Project
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This project explores the role of cyclic adenosine monophosphate (cAMP) in the plasticity of striatal spiny projection neurons, particularly in the context of Parkinson's disease. It employs optogenetic tools to investigate how cAMP influences synaptic and structural changes in these neurons.
The project aims to reveal the so far unknown role of cAMP in structural and synaptic plasticity of striatal spiny projection neurons (SPNs) in health and disease.
Striatal SPNs divide into two subgroups: the dSPNs and iSPNs.
While dSPNs preferentially express the D1 dopamine (DA) receptor, iSPNs express the D2 receptor.
Both are coupled to the cAMP second messenger cascade, however the D1-receptor activates and the D2-receptor inhibits it. DA has therefore opposite effects on the two SPN groups…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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