CORDIS Project
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The scEpiTarget project aims to identify the proteins that regulate histone modifications in a cell-type specific manner. By developing new single-cell techniques, it seeks to understand how these epigenetic changes influence cell differentiation and fate decisions.
Although all cells of an organism share the same genetic information, they selectively access this information in a cell type- and context-dependent manner.
Epigenetic mechanisms, such as post-translational histone modifications (PTHMs) have been identified as central regulators of Transcription Factor-DNA interactions.
During cell differentiation, the distribution of PTHMs is modulated to enable the new cell state.
Most of the protein complexes that position (writer) and remove (eraser) PTHMs h…
AARHUS UNIVERSITET
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