CORDIS Project
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This project explores the role of cannabinoid receptors in schizophrenia, focusing on mitochondrial and astrocytic receptors. It aims to clarify their involvement in psychotic-like behaviors and develop genetic tools for better understanding.
Schizophrenia is a severe psychiatric disorder characterized by a series of ""positive"" and ""negative"" symptoms, which eventually lead to strong sufferance, social isolation and occupational impairment.
Via activation of type-1 cannabinoid receptors (CB1), cannabinoids are known to induce schizophrenic-like symptoms, which are major caveats in the possible therapeutic use of these compounds.
On the other hand, mitochondria-dependent regulation of brain bioenergetics is emerging as a promising…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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