CORDIS Project
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This project investigates the underlying mechanisms of schizophrenia by studying mouse models. It focuses on the role of specific brain interneurons in regulating dopamine levels and aims to develop strategies to normalize their function, potentially improving treatment for cognitive and negative symptoms of the diseas…
Schizophrenia is an incurable disease hallmarked by the presence of positive, negative and cognitive symptoms.
Currently, antipsychotic drugs are used to treat some of the positive symptoms, including psychosis but fail to alleviate cognitive and negative symptoms.
Psychosis is associated with striatal hyperdopaminergia, hypothesized to be due to abnormal activity of midbrain dopamine neurons.
Dopamine levels are already elevated in patients with schizophrenia before the onset of psychosis, sugg…
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