CORDIS Project
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This project investigates the genetic and cellular mechanisms underlying schizophrenia by focusing on excitatory neurons in the brain. By analyzing gene regulatory networks and their effects on other cell types, the research aims to uncover causal relationships that could inform personalized treatment strategies.
Schizophrenia is a heritable but genetically complex disease.
Pathological and epidemiological data fit a model of SCZ as a network disease with perturbations during brain development leading to early-adulthood onset clinical symptomatology.
Our present understanding is based on single markers or arrays of gene expression from tissue samples containing multiple cell types.
As a consequence, pathological changes in the function of inhibitory or excitatory neurons, microglia, or oligodendrocytes h…
KAROLINSKA INSTITUTET
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