CORDIS Project
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This project focuses on developing a gene therapy for spinal cord injury using modified antisense oligonucleotides to target inhibitors of nerve regeneration. It aims to enhance neuronal recovery through a biodegradable delivery system that improves the uptake of therapeutic agents in affected cells.
Spinal cord injury (SCI) leads to severe physical and psychological damages.
Classical pharmacotherapeutics have had limited success to treat this clinical condition and full recovery remains unachievable.
With the understanding of the molecular pathology involved in neuronal injury and regeneration, new molecular targets are now under investigation.
Our aim is to develop an antisense gene therapy approach mediated by single-stranded antisense oligonucleotides (ssAONs), targeted against inhibito…
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
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