CORDIS Project
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This project aims to identify new targets for safer pain relief by exploring the role of specific channels in nerve cells that contribute to chronic pain. It focuses on the relationship between these channels and oxidative stress in various pain models.
Chronic pain, characterized by increased sensitivity to innocuous/mild stimuli (allodynia), afflicts 25% of the European adult population.
Efficacy and/or safety of analgesic medicines is limited, and the treatment of chronic pain associated with inflammation, peripheral and central neuropathies and cancer remains unsatisfactory.
Thus, identification of novel targets for better and safer analgesics is a major medical need.
Transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a su…
UNIVERSITA DEGLI STUDI DI FIRENZE
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