CORDIS Project
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This project investigates the role of epigenetic modifications, specifically DNA and histone methylation, in cardiac hypertrophy, a condition leading to heart failure. By mapping these changes and identifying key enzymes and pathways, the research aims to enhance understanding of transcription regulation and develop ne…
Heart failure is a major cause of mortality and morbidity, and often the consequence of pathological cardiac hypertrophy.
Upon entering hypertrophy, cells undergo a vast transcriptional remodelling, with thousands of genes being either up- or down-regulated.
In the last years it became evident that epigenetic modifications are an important determinant of transcriptional changes, and several lines of evidence demonstrate that epigenome modulating enzymes are implicated in cardiac hypertrophy.
In…
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