CORDIS Project
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This project focuses on creating new compounds to study D-myo-inositol 1,4,5-trisphosphate receptors, which play a crucial role in calcium signaling within cells. The goal is to develop selective antagonists and ligands to better understand these receptors' functions in health and disease, particularly in relation to h…
The overall aim of this project is the development of novel ligands to probe the role of D-myo-inositol 1,4,5-trisphosphate receptors (InsP3Rs) in intracellular calcium signalling.
Two key goals are the development of selective and potent non-inositol InsP3R antagonists and the development of ligands that bind selectively to one of the three subtype of InsP3Rs.
Using hits from an in silico screen, we will develop and then employ thermal shift analysis, surface plasmon resonance and isothermal ti…
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