CORDIS Project
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This project investigates the dual role of Transforming Growth Factor-beta in cancer, aiming to understand its pro-tumorigenic effects while developing selective inhibitors. The goal is to suppress tumor invasiveness and metastasis without completely inhibiting its tumor suppressive functions.
Transforming growth factor-b (TGFb) is a multifunctional cytokine which has important functions during embryonal development and in tissue homeostasis.
In cancer, TGFb is often overexpressed and has both tumor suppressor effects (induction of growth arrest and apoptosis) and tumor promoting effects (stimulation of epithelial-mesenchymal transition (EMT) of tumor cells, stimulation of angiogenesis and cancer associated fibroblasts, and suppression of immune surveillance).Our aim is to elucidate t…
UPPSALA UNIVERSITET
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