CORDIS Project
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This project explores how the thymus contributes to immune system self-tolerance by studying the expression of tissue-specific antigens. It aims to uncover the molecular mechanisms behind this process and its implications for autoimmune diseases.
The thymus plays a central role in the induction of self-tolerance, a hallmark of the immune system.
During T cell development a highly diverse T cell receptor repertoire is probed against a matching array of self-antigens.
While the generation of the T cell receptor repertoire relies on unique genetic recombination mechanisms, the corresponding molecular principles underlying the generation of TCR ligands - self-peptide/MHC complexes - are less well understood; recent data indicate that novel p…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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