CORDIS Project
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This project investigates how early mouse embryos organize themselves during development, focusing on the interplay between molecular signals and physical mechanics. By combining biology and physics, the research aims to uncover the principles of self-organization that lead to the formation of distinct cell lineages in…
A defining feature of multi-cellular living systems is the capacity to break symmetry and generate patterns through self-organisation.
Our project aims to understand the design principle of multi-cellular self-organisation, using a well-suited model system: early mouse embryos.
In mammals eggs lack polarity and symmetry is broken during early embryogenesis, which results in segregation of three cell lineages in the blastocyst.
Progressive expansion and coalescence of fluid-filled spaces form the…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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