CORDIS Project
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This project focuses on developing a variant of the Opi1 peptide that selectively interacts with cardiolipin-containing membranes. By using advanced computational methods and experimental techniques, it aims to enhance the application of these peptides in targeted drug delivery and diagnostics.
Membrane-binding peptides have significant potential applications, such as antimicrobials, biosensors and in the purification of extracellular vesicles.
However, to ensure the effective implementation of these peptides in biotechnological applications, it is essential to prioritize their selectivity.
The Opi1 peptide has previously been shown to exhibit a high affinity for phosphatidic acid (PA)-containing membranes.
Given the analogous structure of cardiolipin (CL), this proposal posits that it…
Masarykova univerzita
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