CORDIS Project
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This project investigates the role of the SEMA3C/NRP1 signaling pathway in the progression of Chronic Kidney Disease (CKD). It aims to understand CKD mechanisms and assess SEMA3C as a potential biomarker for early diagnosis and treatment strategies.
Regardless of the initial insult, human Chronic Kidney Disease (CKD) is characterised by progressive destruction of the renal parenchyma and the loss of functional nephrons.
Renal fibrosis is the common end point of CKDs, the hallmark of which is the deposition of pathological matrix by myofibroblasts.
The worldwide incidence of CKD has reached epidemic proportions with an estimated 10-14% of the adult population known to have CKD. A key challenge for medical planning is to better understand…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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