CORDIS Project
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This project investigates how specific chemical modifications, such as phosphorylation and nitration, affect the behavior of a protein called alpha-synuclein. The goal is to understand its structure, how it forms aggregates, and its localization within cells using advanced chemical biology techniques.
The overall objective of this proposal is to determine the effect of specific disease associated post-translational modifications, more specifically phosphorylation and nitration, on modulating the structural and biochemical properties of a-synuclein.
In detail, we plan to assess the effect of these modifications on i) the structure of monomeric and membrane bound a-synuclein; ii) the oliogmerization and fibrillogenesis of a-syn; iii) subcellular localization and targeting of a-syn to specific c…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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