CORDIS Project
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This project investigates the impact of cellular senescence on skin aging by examining how it affects the extracellular matrix and cell attachment. It aims to identify molecular mechanisms and potential treatments to improve skin health and elasticity as we age.
Skin ageing is characterized by structural changes in the extracellular matrix (ECM) that impair the mechanical properties of the tissue, such as elasticity and stiffness. A key driver of tissue and organismal ageing is cellular senescence, a state of irreversible cell-cycle arrest that triggers functional, metabolic and morphological changes.
The accumulation of senescent fibroblasts in the dermis leads to impaired ECM remodelling and contributes to the mechanical decline associated with skin a…
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