CORDIS Project
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This project investigates how transcription factors regulate gene expression through enhancer elements in response to environmental signals. By studying embryonic stem cells, it aims to uncover mechanisms that ensure cellular plasticity during early development.
Transcription is regulated by transcription factors (TFs) bound at enhancer elements located long-distances from the genes they regulate.
How does this account for dynamic responses to the environment via signaling?
Canonical views invoke signal induced changes in TF expression/modification or cofactor localization, but here we suggest that TF occupancy could be present before and after the signal, establishing competence, ensuring plasticity and blocking premature commitment.
For ERK signaling,…
KOBENHAVNS UNIVERSITET
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