CORDIS Project
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This project investigates how low oxygen levels influence the behavior of senescent cells in age-related diseases like lung cancer and Alzheimer’s disease. It aims to understand the role of hypoxia in shaping the senescence-associated secretory phenotype, which may lead to new therapeutic strategies targeting harmful f…
Research over the last decade has convincingly evidenced that cellular senescence and low oxygen (O2) availability (hypoxia) are distinctive features involved in the physiopathology of age-related disorders including lung cancer and Alzheimer’s disease (AD).
Cellular senescence is characterised by a permanent and irreversible cell cycle arrest and the acquisition of an intense senescence associated secretory phenotype (SASP).
Mounting evidence has shown that the SASP accounts for most of the det…
FUNDACION PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA
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