CORDIS Project
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This project develops a novel antibiotic resistance marker using the CRISPR-Cas system to silence specific bacterial genes. This approach aims to create a user-friendly method for bacterial selection in laboratories and industry, reducing the risk of transferring resistance genes while maintaining effectiveness in vari…
The active spread of antibiotic resistance in laboratories and industry often occurs through the use of plasmids, which transfer resistance genes between bacteria.
To mitigate this, strategies such as non-antibiotic selection methods, stringent containment protocols, and plasmid designs that minimize horizontal gene transfer have been proposed.
However, these strategies often involve complex methodologies and require highly trained personnel.
Recently, our ERC Consolidator results opened the pat…
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