CORDIS Project
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This project investigates rare genetic variants in isolated populations to understand their impact on complex traits, particularly cardiometabolic health. By sequencing genomes and analyzing traits in groups from Crete, Greece, and Korcula, it aims to identify significant genetic associations that could inform future h…
Genome-wide association studies of complex traits have identified many common variant associations, but a substantial heritability gap remains.
The field is shifting towards the study of low frequency and rare variants, hypothesised to have larger effects.
The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and linkage disequilibrium tends to be extended.
This work will focus on three isolated populations, each…
GENOME RESEARCH LIMITED
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