CORDIS Project
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This project focuses on developing new analogues of the antibacterial compound pleuromutilin to combat antibiotic resistance. It aims to create drug-like properties through innovative synthetic processes, enhancing the potential for new therapeutic options.
Resistance to antibiotics is a major concern worldwide and has led to an urgent need to identify antibacterial agents with modes of action distinct from the established classes.
The antibacterial natural product pleuromutilin is such a candidate and has been the focus of biological and medicinal studies in recent years.
Unfortunately, pleuromutilin has poor pharmacokinetic properties and the compound is readily metabolised by enzymes.
Although the natural product itself is not a very good drug,…
THE UNIVERSITY OF MANCHESTER
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