CORDIS Project
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This project explores the regulation of neutrophil serine proteases, which play a dual role in fighting infections and causing tissue damage. It focuses on the protective functions of serpinB1, a protein that inhibits these enzymes, particularly in lung infections and bone marrow health.
Neutrophils are short-lived leukocytes with vital functions in host defense.
Neutrophils are massively recruited to extravascular sites in response to danger signals.
This immediate, life saving, inflammatory response can turn against the host if its intensity and duration are dysregulated leading to tissue injury and/or failed immune response to pathogens.
The dual protective/pathologic role of neutrophils is reflected by the functions of neutrophil serine proteases, potent granule enzymes that…
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