CORDIS Project
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This research investigates the evolutionary causes of sex differences in gene expression using a combination of phylogenetic analysis and experimental manipulation in fruit flies. The goal is to enhance understanding of how these differences arise and their implications for health and biology.
Males and females in many animals are strikingly different in behaviour, physiology, shape and form.
In humans, rates of ageing and disease incidence vary markedly between the sexes.
Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern.
Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4.
Despite their ubiquity and clear…
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