CORDIS Project
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This project investigates the structural and functional properties of the ATRX protein, which is crucial for chromatin remodeling. By exploring its interactions with the DAXX protein and employing various biophysical techniques, the research aims to enhance understanding of ATRX's role in diseases such as ATR-X syndrom…
The eukaryotic genome is packaged into chromatin, which needs to be unpacked to provide necessary access by cellular factors for varied cellular functions.
However, DNA can be rendered accessible by the action of energy-consuming chromatin remodelling proteins.
One such protein is ATRX that harbours an N-terminal plant homeodomain (PHD) and a C-terminal helicase domain that confers ATPase activity and identifies ATRX as a member of the snf2 family member of chromatin remodellers. ATRX has been s…
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