CORDIS Project
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The SHATTER-AML project investigates how cells with complex genomic rearrangements survive and contribute to aggressive cancers like acute myeloid leukemia. By analyzing samples over time using advanced single-cell techniques, it aims to uncover the genetic and non-genetic factors driving cancer progression and resista…
How does a cell with unstable, complex genomic rearrangements stay alive, and even give rise to aggressive, highly resistant malignancies?
This question remains an ultimate research challenge for cancers with highly aberrant genomes, such as acute myeloid leukemia with complex karyotype (CK-AML).
Its etiology, time-resolved clonal dynamics, molecular heterogeneity, and treatment resistance mechanisms are still largely elusive.
In particular, the genetic and non-genetic dynamics that drive cancer…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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