CORDIS Project
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This project investigates the role of telomeres in cancer, focusing on the shelterin complex and its mutations. By creating specific mouse models, it aims to develop new therapeutic strategies targeting telomere maintenance mechanisms to inhibit cancer cell growth.
Telomeres are protective structures at the chromosome ends essential for genome stability.
Telomere biology is intricately linked with human cancer.
Most cancer cells reactivate telomerase to avoid telomere loss associated to cell division.
Targeting telomerase inhibition in cancer has shown very limited efficacy, alternative or additional mechanisms of telomere maintenance are thus at play in cancer.
Recent evidence shows that components of the telomere-protecting shelterin complex are mutated…
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