CORDIS Project
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This project investigates the metabolism of C11-oxy androgens in fetal development, focusing on how cytochrome P450 enzymes produce novel metabolites. Using advanced mass spectrometry, it aims to identify these metabolites and enhance understanding of their role in human health and disease.
Steroid hormones, produced by the fetal adrenal, are metabolised by the fetal liver and placenta thereby regulating fetal development.
Consequently, these steroids are also implicated in endocrine-related disorders and diseases that present in the fetal and neonatal stage.
The major fetal liver cytochrome P450 enzyme, CYP3A7, catalyses the production of 16α-hydroxy-dehydroepiandrosterone (16α-hydroxy DHEA) leading to the biosynthesis of the 16α-hydroxy estrogen of pregnancy, estriol, in the plac…
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