CORDIS Project
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This project focuses on understanding the molecular interactions of the inducible co-stimulator and its ligand, which play critical roles in immune responses. The goal is to provide insights that could lead to new therapies for autoimmune diseases and cancer.
T and B lymphocytes are effectors of adaptive immunity.
Their dysregulation have dramatic health consequences, and can lead to autoimmunity and blood cancers.
Recently, immune receptors involved in dictating the fate of B and T cells have expanded drastically.
Once of these critical receptor/ligand immune pair is the inducible co-stimulator (ICOS) and its ligand ICOSL, which emerged as a novel T/B-cell co-signaling pathway.
The multiple roles reported for this immune complex position ICOS/ICOSL…
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
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