CORDIS Project
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This project investigates the role of DNA single-strand breaks in neurodegeneration and their contribution to diseases like amyotrophic lateral sclerosis. It aims to identify the mechanisms involved and explore potential therapeutic targets.
DNA single-strand breaks (SSBs) are the most frequent DNA lesions arising in cells and are a major threat to cell survival and genome integrity, as indicated by the elevated genetic deletion, embryonic lethality, or neurological disease observed if single-strand break repair (SSBR) is attenuated.
In particular, SSBR defects are associated with hereditary neurodegeneration in humans, as illustrated by the genetic diseases ataxia oculomotor apraxia-1 (AOA1), spinocerebellar ataxia with axonal neur…
THE UNIVERSITY OF SUSSEX
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UMG INSTITUTE OF MOLECULAR GENETICS ACA SCIEN CZECH REPU
Czechia, Praha 4
Type: Research institute
Activity type: Research Organisations
SME: No
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