CORDIS Project
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This project investigates how early cell fate decisions occur in developing mouse embryos, focusing on the role of Oct4, a key transcription factor. By analyzing Oct4 kinetics, the project aims to understand lineage patterning and the establishment of pluripotent states in embryos.
There is a long-running controversy about how early cell fate decisions are made in the developing mammalian embryo.
In particular, it is controversial when the first events that can predict the establishment of the pluripotent and extra-embryonic lineages in the blastocyst occur.
It has long been proposed that the position and polarity of cells at the 16- to 32-cell stage embryo influence their decision to either give rise to the pluripotent cell lineage that eventually contributes to the inner…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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